OBSESSIVE–COMPULSIVE DISORDER (OCD) IS A COMMON and debilitating
neuropsychiatric disorder. Although it is widely believed to have a genetic basis, no specific …

Interest in the possibility of an immune-mediated pathophysiology of obsessive–compulsive
disorder and related disorders has increased. In the late 1980s, the National Institute of …

The precise cause of tic disorders and paediatric obsessive-compulsive disorder (OCD) is
unknown. In addition to genetic factors, autoimmunity may play a role, possibly as a sequela …

During the last few years, an increased interest in the possibility of immune mediated
pathophysiology of obsessive compulsive disorder (OCD) and related disorders has been …

Over a century ago, Sir William Osler wrote,“To carefully observe the phenomena of life in all
its phases... to call to aid the science of experimentation, to cultivate the reasoning faculty, so …

A subgroup of childhood-onset obsessive-compulsive disorder (OCD) and tic disorders has
been found to have a postinfectious autoimmune-mediated etiology. Clinical observations …

The evidence to date, both published and unpublished, which addresses the validity of the
proposed unique subgroup of children with early and abrupt onset of obsessive–compulsive …

Autoimmunity associated with a streptococcal infection has been proposed as a pathogenic
mechanism for obsessive–compulsive disorder (OCD) in children. Antibrain antibody …

The boundaries between obsessive-compulsive disorder (OCD) and other neuropsychiatric
disorders remain unresolved and may well differ from one disorder to another …

OBJECTIVES: A commonality across a number of pediatric neuropsychiatric disorders is a
higher than typical rate of familial—and especially maternal—autoimmune disease. Of …