Like the preparation of a complex legalbrief, the design, execution and analysis of a clinical
trial require a carefulstudy of previous cases, diligent research anda canny presentation of …

One of the earliest talking pictures' Arrowsmith', circa 1931, brought the ethical problem of
clinical trials to the attention of the general public. In it, Ronald Colman portrayed a gifted …

Many medical investigators now think that prospective randomized clinical trials offer the
most reliable way of comparing alternative treatments. Although the concepts of randomized …

SIR,-There may be confusion arising from the juxtaposition of two points in your leading
article on this subject (11 November, p 1318). Frieman et al," in their survey of 71" negative" …

In attaching the label “keynote” to my remarks, the Program Committee took a grave risk.
Some works of music, like Beethoven's First Symphony, start in the wrong key, and have to …

In the 36 years that have passed since the end of the Second World War, the clinical trial,
which it goes without saying includes a control series, has come to play a progressively …

In this issue of the Journal (starting on page 365) Miller and colleagues report the results of
a national clinical trial comparing two chemotherapeutic regimens in the treatment of …

Clinical trials: Some reflections Page 1 STATISTICS IN MEDICINE, VOL. I, 361-368 (1982)
CLINICAL TRIALS: SOME REFLECTIONS WALTER W. HOLLAND, ELLIE BREEZE AND …

1. Background The historical background of medical clinical trials is presented in an
excellent article by Bull (1959). In the context of more recent events and clinical trials some …

I his is the first in a series of four articles focusing on clinical trials which will appear in this
Journal in the next several issues. This article will present some ethical and design issues …