Discussion In this illustrative case, adrenal insufficiency developed in our patient when
ritonavir, a potent inhibitor of the cytochrome P450 (CYP) 3A4 pathway, was withdrawn …

Methods We report a case of iatrogenic adrenal insufficiency interaction secondary to
ritonavir and inhaled fluticasone in an HIV-infected patient with COPD. A review was made …

A 52-year-old man with well-controlled HIV infection taking ritonavir and increasing doses of
inhaled fluticasone for chronic bronchitis developed thrush. Within days of discontinuing …

A 48-year-old woman with HIV infection developed Cushingoid features while she was
taking ritonavir-boosted darunavir. Cushing's syndrome was confirmed due to the drug …

Ritonavir is a potent inhibitor of the cytochrome P450 enzyme CYP3A4 and is subject to
multiple drug–drug interactions. This becomes especially important when the patient is also …

Ritonavir is a potent inhibitor of the cytochrome P450 3A4 enzyme and is used to increase
the bio-availability of protease inhibitors in the management of HIV infection. The …

Discussion Adrenal suppression with ritonavir and concomitant fluticasone has been
described in children and adolescents, 2, 4 and it has been suggested that other inhaled …

Ritonavir and atazanavir (ATZ) are protease inhibitors (PI) that inhibit the P450 3A4
cytochrome. They are used together to boost ATZ levels and reduce pill burden in human …

Discussion. Budesonide is inactivated through extensive first-pass metabolism by hepatic
CYP3A4. The P-glycoprotein (PGP) export pump also limits budesonide serum …

A36-year-old woman with HIV presented with recent weight gain, marked abdominal striae
and proximal muscle weakness. She had a four-year history of type 2 diabetes mellitus that …