An and Goodwin appropriately detail the use of flumazenil in select circumstances of
benzodiazepine overdosing. 1 As also suggested, most patients with benzodiazepine …

Zopiclone is a cyclopyrrolone sedative-hypnotic structurally unrelated to benzodiazepines
(1). Its pharmacological effects, however, are similar to those of benzodiazepines (1–3) …

Benzodiazepines promote the binding of γ-aminobutyric acid (GABA) to its receptor. The “Z”
drugs (zopiclone, zaleplon and zolpidem) act in a similar manner. Flumazenil is a …

Discussion Zopiclone is a cyclopyrrolone hypnotic drug that modulates GABA-A receptors.
The binding of zopiclone does not appear to be facilitated by GABA, and unlike …

Ahmad et al. reported a 55-year-old schizophrenic man who was unconscious after
zopiclone overdose (8). The patient also received several regular medications, including …

The worldwide expansion in the use of benzodiazepines has led to their frequent, and often
inappropriate, use and to an increase in their involvement in self-induced poisoning and …

Flumazenil is an effective benzodiazepine (BDZ) antagonist, but its usefulness in managing
BDZ overdose (OD) is limited by its potential to precipitate seizure. The approach of UK …

Objective Benzodiazepine (BZD) overdose (OD) continues to cause significant morbidity
and mortality in the UK. Flumazenil is an effective antidote but there is a risk of seizures …

Discussion: Flumazenil acts as a competitive antagonist on the GABA receptor through the
GABA/benzodiazepine receptor complex, acting as a specific antidote to benzodiazepine …

Dear Editor, We read with interest the current MiniReview performed on a common topic of
clinical toxicology [1]. Our hospital records show that more than 22%(24,185 hospitalized …