(ASA) and statins for primary cardiovascular prevention, and, in COPD, phosphodiesterase-
4 inhibitors. These drugs have preventive effects (eg, prevention of myocardial infarction by …

Conclusion: The Zafari equation predicting future FEV1 values performed robustly in UK
electronic medical data, similar to reported validation results of two external randomized …

Background An individualized FEV 1 prediction model has recently been developed based
on the Lung Health Study (LHS). An ongoing evaluation of the utility of prediction models in …

Background: The rate of lung-function decline in chronic obstructive pulmonary disease
(COPD) varies substantially among individuals. We sought to develop and validate an …

Understanding baseline characteristics that can predict the progression of lung disease
such as chronic obstructive pulmonary disease (COPD) for current or former smokers may …

Background Prediction of future lung function will enable the identification of individuals at
high risk of developing COPD, but the trajectory of lung function decline varies greatly …

Background Chronic Obstructive Pulmonary Disease (COPD) is the third main cause of
death worldwide (WHO, 2014). For 2013, in Portugal 2,720 deaths were associated to …

Background: Risk factor identification is a proven strategy in advancing treatments and
preventive therapy for many chronic conditions. Quantifying the impact of those risk factors …

Personalised medicine aims to tailor medical decisions to the individual patient. A possible
approach is to stratify patients according to the risk of adverse outcomes such as …

Objective: We aim to make use of clinical spirometry data in order to identify individual
COPD-patients with divergent trajectories of lung function over time. Study Design and …