Proton pump inhibitors have been a cornerstone in the treatment of gastresophageal reflux
disease and peptic ulcer disease since their introduction in the late 1980s. Gastresophageal …

Dear Editor, Two studies in 2000 and 2001, both conducted using the UK General Practice
Research Database (GPRD), reported conflicting results on the potential beneficial effects of …

Objectives The purpose of this study was to reconfirm the association between the risk of
fracture and proton pump inhibitor use and to establish evidence for defining a high-risk …

Opinion Statement There are 34 studies in almost 2 million participants that have reported
on the association between proton pump inhibitor (PPI) therapy and risk of fracture. There is …

“When prescribing proton pump inhibitors, health professionals should consider whether a
lower dose or shorter duration of therapy would adequately treat the patient's condition,” …

594 Can J Gastroenterol Vol 27 No 10 October 2013 with fracture. Yang et al (6) found
antipsychotics, anti-Parkinsonian, and antiseizure drugs were all associated with increased …

OBJECTIVES: Proton pump inhibitors (PPIs) are widely used in several acid-related
gastrointestinal disorders. In vivostudies have suggested that gastric suppression by PPIs …

Proton pump inhibitors (PPIs) are among the most commonly prescribed medications today
with an excellent short-term safety profile. Recently, a number of studies from a variety of …

Osteoporotic fractures, particularly hip fractures, can have a devastating impact on the well-
being of the elderly population. Recently, two population-based observational studies …

Proton pump inhibitors (PPIs) are commonly used drugs, several of which are available
without a prescription. Two recent studies have demonstrated increased hip fracture rates …