Findings from subgroup analyses have been inconsistent, and need verification. analyses,
particularly those pertaining to interactions between sex and serum digoxin concentration …

Digoxin remains one of the oldest therapies for heart failure; however, its safety and efficacy
have been controversial since its initial use. Questions that remain include the clinical …

Digitalis is the oldest compound in cardiovascular medicine that continues to be used in
contemporary clinical practice. 1 Evidence supporting the beneficial effects of digoxin on …

Digoxin and diuretics were once the cornerstones of therapy for patients with chronic heart
failure. During the past 2 decades, an increasing number of therapeutic options for the …

Digoxin improves exercise tolerance and reduces hospitalizations in patients with systolic
heart failure, but its use has declined progressively for the past two decades. The Digitalis …

Our study, published in the October 31, 2002 issue of the New England Journal of Medicine,
identified a statically and clinically significant interaction between patient sex and digoxin …

the DIG trial, which showed a lack of mortality benefit from digoxin, nor the subgroup
analysis that suggested potential harm from digoxin in women. 1, 7 In the DIG trial, digoxin …

Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries.
Now that newer therapies have been introduced that reduce the mortality rate in heart failure …

Digoxin therapy is used to treat heart failure patients for more than 200 years. However,
absence of effect on overall mortality found in the DIG study associated with frequent …

Digoxin therapy has long been used to treat heart failure; however, its effectiveness was not
completely known until recently. Results of the Digitalis Investigation Group trial showed that …