Reason for posting: A change in the prescribing information for venlafaxine has been issued
by the US manufacturer, based on concerns that the antidepressant drug has been …

Discussion Venlafaxine is a serotonin-norepinephrine reuptake inhibitor and is commonly
prescribed for moderate to severe depression. It is available in immediate-or extended …

The antidepressant venlafaxine in overdose can lead to serotonin syndrome, seizures, QTc
interval prolongation and can increase the risk of cardiac arrhythmias. It has been reported …

Background: Selective serotonin reuptake inhibitors (SSRIs) and venlafaxine have been
regarded as less toxic in overdose than tricyclic antidepressants (TCAs). Within the TCAs …

Context: Desvenlafaxine is used to treat major depression. Desvenlafaxine is also the active
metabolite of venlafaxine. Venlafaxine overdose can cause serotonin toxicity, seizures and …

The need to reduce unwanted effects and improve the safety profile of a drug, particularly in
overdose, must be an important consideration when assessing the overall value of a new …

Venlafaxine (VEN) is an antidepressant found to possess a higher fatal toxicity index (FTI, ie,
deaths in proportion to consumption) than other newer antidepressants and selective …

Depression and anxiety disorders are among the most common disorders treated by general
practitioners (GPs) in the UK. Since both disorders are associated with a significantly …

Background: Venlafaxine is an antidepressant whose adverse event profile is similar to that
of the SSRIs (selective serotonin reuptake inhibitors). Serious complications due to …

Objective To investigate likelihood of self-harm by overdose with antidepressant drugs of
different types by examining hospital admission data and poisons inquiries and relating …