Delirium after elective surgery among elderly patients taking statins

DA Redelmeier, D Thiruchelvam, N Daneman - Cmaj, 2008 - Can Med Assoc
Background: Postoperative delirium after elective surgery is frequent and potentially serious.
We sought to determine whether the use of statin medications was associated with a higher …

Preoperative statins are associated with a reduced risk of postoperative delirium following vascular surgery

DS Lee, MY Lee, CM Park, DI Kim, YW Kim, YJ Park - PLoS One, 2018 - journals.plos.org
Delirium is a common complication of vascular surgery. The protective effect of preoperative
statins on delirium after vascular surgery is controversial. The authors hypothesized that …

Preoperative use of statins is associated with reduced early delirium rates after cardiac surgery

R Katznelson, GN Djaiani, MA Borger… - The Journal of the …, 2009 - pubs.asahq.org
Background Delirium is an acute deterioration of brain function characterized by fluctuating
consciousness and an inability to maintain attention. Use of statins has been shown to …

Preoperative statin therapy is not associated with a decrease in the incidence of delirium after cardiac operations

G Mariscalco, M Cottini, M Zanobini, S Salis… - The Annals of thoracic …, 2012 - Elsevier
BACKGROUND: Delirium after cardiac operations is associated with significant morbidity
and death. Statins have been recently suggested to exert protective cerebral effects. This …

Role of statins in delirium prevention in critical ill and cardiac surgery patients: A systematic review and meta-analysis

S Vallabhajosyula, A Kanmanthareddy, PJ Erwin… - Journal of critical …, 2017 - Elsevier
Background The data evaluating the role of statins in delirium prevention in the intensive
care unit are conflicting and limited. Methods We performed a systematic review and meta …

Statins and delirium during critical illness: a multicenter, prospective cohort study

A Morandi, CG Hughes, JL Thompson… - Critical care …, 2014 - journals.lww.com
Objective: Since statins have pleiotropic effects on inflammation and coagulation that may
interrupt delirium pathogenesis, we tested the hypotheses that statin exposure is associated …

Statin and its association with delirium in the medical ICU

JF Mather, JP Corradi, C Waszynski, A Noyes… - Critical care …, 2017 - journals.lww.com
Objectives: To examine the association between statin use and the risk of delirium in
hospitalized patients with an admission to the medical ICU. Design: Retrospective …

Statin withdrawal after major noncardiac surgery: risks, consequences, and preventative strategies

N Fallouh, V Chopra - Journal of hospital medicine, 2012 - Wiley Online Library
BACKGROUND: A growing body of research suggests that statins improve perioperative
cardiac outcomes by attenuating inflammation. Conversely, some studies suggest that …

Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass

JP Mathew, HP Grocott, JR McCurdy II, LK Ti… - Journal of cardiothoracic …, 2005 - Elsevier
Objective: The purpose of this study was to determine if patients receiving statin therapy
before coronary artery bypass grafting surgery would have less cognitive dysfunction after …

Independent vascular and cognitive risk factors for postoperative delirium

JL Rudolph, RN Jones, LS Rasmussen… - The American journal of …, 2007 - Elsevier
BACKGROUND: Delirium is a common, morbid, and costly syndrome that occurs frequently
after surgery for atherosclerosis. We hypothesized that vascular risk factors and mildly …