The results of these studies help to explain the association between Nod2 mutations and
Crohn's disease. In finding Nod2 to be an important immune mediator in the intestine, the …

The search for genetic associations in Crohn's disease has led to several fruitful discoveries
that hold the potential to identify pathogenetic mechanisms and targets for future therapy …

Scientists' motivation for identifying susceptibility genes for Crohn's disease (CD) include an
increased understanding of disease etiology and pathogenesis, the development of …

Bevins CL, Stange EF, Wehkamp J. Decreased Paneth cell defensin expression in ileal
Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype …

1Laboratory of Experimental Internal Medicine, 2Department of Gastroenterology and
Hepatology, Academic Medical Centre, Amsterdam, the Netherlands, tel.:+ 31 (0) 20-566 91 …

Background and aims: Genetic variation in NOD2 has been associated with susceptibility to
Crohn's disease (CD) and specifically with ileal involvement. The reason for the unique …

Studies of Crohn's disease have consistently implicated NOD2 as the most important gene
in disease pathogenesis since first being identified in 2001. Thereafter, genome-wide …

Approximately 15% of patients with inflammatory bowel disease (IBD) have first-degree
relatives who also have IBD. The best estimates of the lifetime risk of developing IBD among …

Background and aims: Reduced ileal Paneth cell α-defensin expression has been reported
to be associated with Crohn's disease, especially in patients carrying NOD2 mutations. The …

Crohn's disease (CD) is a chronic, relapsing inflammatory disorder of the intestinal mucosa
usually starting in young adults, causing a life-long burden for the patients. CD may occur …