Commentary Commentaire methodologists who don't diagnose and treat individual patients.
Second, and in part as a consequence of the first, the latter group frequently comes across …

It is not surprising that David Sack-ett1, 2 disagrees with Stanley Shapiro and Kathleen
Glass; 3 they are talking about different things. A clinical trial involves decisions at 3 distinct …

Clinical equipoise, or uncertainty about which treatment is best for a patient, is widely
viewed as essential for an ethical RCT. The authors argue that clinical trials that violate …

Background Benjamin Freedman has argued in 1987 that before a controlled trial is started,
there should be 'genuine uncertainty in the expert medical community about the preferred …

Clinical research employing the randomized clinical trial has, traditionally, been understood
to pose an ethical dilemma. On the one hand, each patient ought to get the treatment that …

Background This conception of clinical equipoise—as rooted in the uncertainty of the
community of medical experts—emerged in response to an earlier (and perhaps more …

When may a physician legitimately offer enrollment in a randomized clinical trial (RCT) to
her patient? Two answers to this question have had a profound impact on the research …

Clinical equipoise is widely regarded as an ethical requirement for the design and conduct
of randomized controlled trials (RCTs). Underlying clinical equipoise is the norm that no …

Equipoise is advocated as a means of achieving high scientific and ethical standards in
randomised trials. As used in the context of research the word describes a state of …

As clinicians, researchers, bioethicists, and members of society, we face a number of moral
dilemmas concerning randomized clinical trials. How we manage the starting and stopping …