Background Hypertension increases the risk of morbidity and mortality from cardiovascular
disease. 1 Canadian guidelines recommend the use of diuretics, β-adrenergic blockers or …

To the Editor: In their Commentary, Dr Psaty and colleagues1 stated that recent meta-
analyses by Carlberg et al2 and Lindholm et al3 confirm their own previous metaanalysis. 4 …

The classic outcome trials in hypertension, most of which used diuretics and β-blocking
agents as first-line antihypertensive agents, have shown that antihypertensive drug …

The antihypertensive drug classes that have reduced cardiovascular events safely either in
large placebo-controlled trials or in comparison with other effective antihypertensive drugs in …

Hypertension is strongly associated with increased cardiovascular events if left uncontrolled.
By the end of the twentieth century, many antihypertensive medications were widely …

Objective: To evaluate the effects of β-adrenergic antagonist therapy on cardiovascular and
cerebrovascular outcomes in the treatment of hypertension. Data Sources: Literature …

Over the past decade, national and international guidelines have proposed beta-blockers to
be used on an equal footing with diuretics for initial therapy of hypertension. This preferred …

As Westernised societies have become more affluent, the attitudes of the population have
become more risk-aware. People are now intolerant of small risks as well as the physical or …

Recent trials have helped to clarify indications for the initial pharmacological therapy of
hypertension. Both the Joint National Committee on Prevention, Detection, Evaluation, and …

Hypertension is one of the most common disorders in the United States, affecting
approximately 50 million people. 1 Hypertension is a major independent risk factor for …