Differential effect of ticagrelor versus clopidogrel by homocysteine levels on risk of recurrent stroke: a post hoc analysis of the CHANCE-2 trial

A Wang, X Tian, X Xie, H Li, PM Bath, J Jing, J Lin… - CMAJ, 2024 - Can Med Assoc
Background: Elevated homocysteine levels are associated with increased blood coagulation
and platelet activity and may modulate the response to antiplatelet therapies. We aimed to …

Homocysteine level predicts response to dual antiplatelet in women with minor stroke or transient ischemic attack: subanalysis of the chance trial

J Li, Y Wang, H Li, Z Zuo, J Lin, A Wang… - … and Vascular Biology, 2020 - Am Heart Assoc
Objectives: To investigate the relationship of homocysteine levels with the efficacy and
safety of dual antiplatelet therapy in female and male patients. Approach and Results: The …

The introduction of ticagrelor is associated with lower rates of recurrent ischemic stroke after myocardial infarction

R Henriksson, F Björklund, T Mooe - Plos one, 2019 - journals.plos.org
Background Previous ischemic stroke is a predictor of recurrent ischemic stroke after an
acute myocardial infarction (AMI). Dual antiplatelet therapy, including a P2Y12-inhibitor, is …

Efficacy and Safety of Ticagrelor versus Aspirin and Clopidogrel for Stroke Prevention in Patients with Vascular Disease: A Systematic Review and Meta-Analysis

XMDLSLYC PingZhong - 2023 - karger.com
Introduction: Currently, it is still controversial to treat stroke with ticagrelor alone. The
purpose of our study was to systematically review and analyze the efficacy and safety of …

Efficacy and safety of ticagrelor versus aspirin and clopidogrel for stroke prevention in patients with vascular disease: a systematic review and meta-analysis

X Ma, D Li, S Liu, Y Chen, P Zhong - European Neurology, 2023 - karger.com
Introduction: Currently, it is still controversial to treat stroke with ticagrelor alone. The
purpose of our study was to systematically review and analyze the efficacy and safety of …

Dual antiplatelet therapy with ticagrelor may increase the risk of all bleeding events in patients with minor strokes or high risk TIAs: a meta-analysis

X Chen, J Xu, S Chen, Q Dong, Y Dong - Stroke and Vascular …, 2022 - svn.bmj.com
In the Acute Stroke or TIA Treated with Aspirin or Ticagrelor and Patient Outcomes
(SOCRATES) trial, ticagrelor was not superior to aspirin in reducing the risk of the composite …

Increased Use of Ticagrelor After Myocardial Infarction Is Not Associated With Intracranial Hemorrhage: Results From a Nationwide Swedish Registry

A Graipe, L Söderström, T Mooe - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Guidelines recommend dual antiplatelet treatment with
ticagrelor instead of clopidogrel after acute myocardial infarction. Ticagrelor increases major …

Abstract P1: Antiplatelet Therapy for Secondary Prevention After Ischemic Stroke: Systematic Review and a Network Meta-Analysis From Randomized Trials

T Mikami, M Sakamoto, T Kuno, A Machida, E Siau… - Stroke, 2021 - Am Heart Assoc
Introduction: While various antiplatelet regimens are currently available for secondary
prevention after ischemic stroke, data comparing their efficacy and safety are scarce. We …

Impact of smoking on platelet function of ticagrelor versus clopidogrel in minor stroke or transient ischaemic attack

Y Yang, W Chen, X Meng, L Liu, Y Wang… - European Journal of …, 2020 - Wiley Online Library
Background and purpose It remains unclear whether smoking status has an impact on
platelet reactivity and clinical outcomes of ticagrelor versus clopidogrel in patients with acute …

Is clopidogrel the antiplatelet drug of choice for high‐risk patients with stroke/TIA?: yes

HC DIENER - Journal of Thrombosis and Haemostasis, 2005 - jthjournal.org
Recurrence risk after transient ischemic attack (TIA) or ischemic stroke (IS) ranges from 5 to
20% per year [1–3]. The risk is highest immediately after the first event [4–6]. Numerous trials …