Thank you for bringing this important issue to the attention of CMAJ's readership. 1 As
clinicians, we all wish to deliver evidence-based and effective pain treatment to our patients …

Codeine is, second only to morphine, the most widely used narcotic analgesic. 1 Health
professionals and the public generally believe that codeine, used responsibly, is safe, a …

Codeine is an old and commonly used analgesic agent for mild to moderate pain. It is the
prototypical “prodrug” in that its analgesic effect is almost wholly dependent on its …

Opioids remain the agent of choice for the treatment of moderate to severe pain in both
adults and children. Codeine, an opioid analogue, is commonly used in the treatment of mild …

If pain is not treated quickly and effectively in children, it can cause long-term physical and
psychological sequelae. Therefore, it is important for all health care providers to understand …

Introduction The objective of this systematic review is to reflect on assumptions in relation to
codeine use in combination with other analgesics. Methods MEDLINE was searched …

Codeine is a weak opioid analgesic. It has to be converted to morphine, but there is
significant inter-individual variation in its pharmacokinetics which results in variable …

Codeine is a mild opioid widely used as an analgesic in various age groups, including
various pediatric settings. It is a prodrug that owes its analgesic effect almost entirely to the …

In April 2017, the US Food and Drug Administration (FDA) issued a contraindication to the
drug label of codeine, alerting prescribers that codeine should not be used to treat pain or …

As a weak opioid, codeine has been prescribed for a range of painful conditions. For mild-to-
moderate pain, the combination of ibuprofen and acetaminophen is just as or more effective …