Tranexamic acid for trauma-related hemorrhage

A Ackery, S Rizoli - CMAJ, 2014 - Can Med Assoc
Uncontrolled hemorrhage causes 30%–45% of all trauma-related deaths. The Clinical
Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial, an …

Tranexamic acid for trauma patients—more lives to save and outcomes to consider

H Shakur-Still, I Roberts - New England Journal of Medicine, 2023 - Mass Medical Soc
Traumatic hemorrhage accounts for approximately 2 million deaths each year worldwide. 1
In 2010, the results of the Clinical Randomisation of an Antifibrinolytic in Significant …

Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial

I Roberts, P Perel, D Prieto-Merino, H Shakur, T Coats… - Bmj, 2012 - bmj.com
Objectives To examine whether the effect of tranexamic acid on the risk of death and
thrombotic events in patients with traumatic bleeding varies according to baseline risk of …

Tranexamic acid therapy decreases mortality of traumatic hemorrhagic shock

A Muñoz-Sánchez, F Murillo-Cabezas - Medicina Intensiva (English Edition), 2011 - Elsevier
The CRASH 2, a randomized, double-blind, controlled trial that enrolled 20,211 adult trauma
patients, has shown that the administration of tranexamic acid significantly reduces all-cause …

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial

Crash-2 Collaborators - The Lancet, 2011 - Elsevier
BACKGROUND: The aim of the CRASH-2 trial was to assess the effects of early
administration of tranexamic acid on death, vascular occlusive events, and blood transfusion …

Tranexamic acid treatment for trauma victims

I Roberts, A Brenner… - Seminars in thrombosis …, 2021 - thieme-connect.com
Worldwide, traumatic injury is responsible for over 5 million deaths per year, the majority due
to exsanguination and head injury. The antifibrinolytic drug tranexamic acid is the only drug …

[HTML][HTML] Use of tranexamic acid in major trauma: a sex-disaggregated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH …

T Nutbeam, I Roberts, L Weekes, H Shakur-Still… - British Journal of …, 2022 - Elsevier
Background Women are less likely than men to receive some emergency treatments. This
study examines whether the effect of tranexamic acid (TXA) on mortality in trauma patients …

[HTML][HTML] Tranexamic acid–A recipe for saving lives in traumatic bleeding

I Roberts - Alexandria Journal of Medicine, 2012 - Taylor & Francis
Using kitchen scales, carefully weight out 4 kg of rice and pour it into a deep saucepan. Now
put your hands into the rice and let the grains run between your fingers. Contemplate …

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant hemorrhage (CRASH-2): a randomized …

H Shakur, I Roberts - 50 Landmark Papers every Trauma …, 2019 - api.taylorfrancis.com
This important paper addressed a key clinical question, which was exceptionally novel at the
time of investigation. Namely, could the early administration of 1 gram of tranexamic acid …

Tranexamic acid in trauma: After 3 hours from injury, when is it safe and effective to use again?

CD Barrett, MD Neal, JG Schoenecker… - …, 2024 - Wiley Online Library
Tranexamic acid (TXA) has proven mortality benefit if used early after traumatic injury, likely
related to a combination of bleeding reduction and other non‐bleeding effects. If TXA is …