Published at www. cmaj. ca on Dec. 13, 2006. cant. If this view of human cancer continues to
gain experimental support, it is likely that our current strategies may have emphasized the …

A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

The “cancer stem cell” hypothesis is receiving increasing interest and has become the object
of considerable debate among cancer biologists and clinicians. This ongoing debate is …

Stem cells and cancer are inextricably linked; the process of carcinogenesis initially affects
normal stem cells or their closely related progenitors and then, at some point, neoplastic …

A cell that can both self-renew, that is, regenerate itself, and differentiate along a particular
lineage to give rise to the heterogeneity of cells within a tumor. The putative enrichment of …

The relationships between cancer and stemness have a long history that is traced here.
From the mid-19th century when the first theory on the embryonic origin of cancer was …

The idea, if right, could explain why tumors often regenerate even after being almost
destroyed by anticancer drugs. It also points to a different strategy for developing anticancer …

Cancer stem cells and their potential roles in tumor heterogeneity are currently subjects of
intense investigation. Studies suggest that these cells may develop from any normal cell and …

Cancer has been known to arise from long-lived cells in the body and to possess properties
in common with undifferentiated, embryonic cells. Recent findings of a population of cells in …

Cancer remains a major cause of death and although a better understanding of cancer
mechanisms has enabled increasing therapeutic success for some types of malignancy, for …