Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

[HTML][HTML] Inflammation and vitamin D: the infection connection

M Mangin, R Sinha, K Fincher - Inflammation Research, 2014 - Springer
Introduction Inflammation is believed to be a contributing factor to many chronic diseases.
The influence of vitamin D deficiency on inflammation is being explored but studies have not …

Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine

R Bouillon, NM Van Schoor, E Gielen… - The Journal of …, 2013 - academic.oup.com
Context: Public health authorities around the world recommend widely variable
supplementation strategies for adults, whereas several professional organizations, including …

U‐shaped association between serum 25‐hydroxyvitamin D and fracture risk in older men: results from the prospective population‐based CHAMP study

K Bleicher, RG Cumming, V Naganathan… - Journal of Bone and …, 2014 - academic.oup.com
The aim of this population‐based, prospective, observational study was to examine the
relationship between serum levels of 25‐hydroxyvitamin D (25OHD) and fracture risk in a …

Altered cord serum 25‐hydroxyvitamin D signaling and placental inflammation is associated with pre‐term birth

S Budhwar, P Verma, R Verma, S Gupta… - American Journal of …, 2020 - Wiley Online Library
Problem Vitamin D is well‐known for having anti‐inflammatory and immunomodulatory
properties. Impaired maternal vitamin D status has been known to increase the risk of …

[HTML][HTML] Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

J Deelen, EB van den Akker, S Trompet… - Experimental …, 2016 - Elsevier
Genetic studies have thus far identified a limited number of loci associated with human
longevity by applying age at death or survival up to advanced ages as phenotype. As an …

Vitamin D in physiological and pathological aging: Lesson from centenarians

E Ferri, M Casati, M Cesari, G Vitale… - Reviews in Endocrine and …, 2019 - Springer
Vitamin D is a secosteroid hormone that exerts a pleiotropic action on a wide spectrum of
tissues, apparatuses and systems. Thus, vitamin D has assumed an increasingly dominant …

[HTML][HTML] Vitamin D and extraskeletal health

R Bouillon, CJ Rosen, JE Mulder - UpToDate, 2015 - medilib.ir
INTRODUCTION—Vitamin D deficiency was originally discovered as the cause of rickets
due to lack of exposure to sunshine or vitamin D-rich food. This disease is still endemic in …

The IOM–Endocrine Society controversy on recommended vitamin D targets: in support of the IOM position

R Bouillon, C Rosen - Vitamin D, 2018 - Elsevier
The causal link between vitamin D status and bone health is very strong, as vitamin D
deficiency causes most cases of rickets and osteomalacia. Vitamin D is also causally linked …

The effect of calcium and vitamin D supplementation on osteoporotic rabbit bones studied by vibrational spectroscopy

A Lani, N Kourkoumelis, G Baliouskas… - Journal of biological …, 2014 - Springer
Fourier transform infrared spectroscopy is utilized to examine the effects of increased
calcium, vitamin D, and combined calcium-vitamin D supplementation on osteoporotic rabbit …