Disease-modifying drugs in osteoarthritis: current understanding and future therapeutics
WM Oo, SPC Yu, MS Daniel… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Osteoarthritis (OA) is a leading cause of pain and disability among adults with a
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …
A review of advanced small‐scale parallel bioreactor technology for accelerated process development: Current state and future need
R Bareither, D Pollard - Biotechnology progress, 2011 - Wiley Online Library
The pharmaceutical and biotech industries face continued pressure to reduce development
costs and accelerate process development. This challenge occurs alongside the need for …
costs and accelerate process development. This challenge occurs alongside the need for …
The use of pharmacoepidemiology to study beneficial drug effects
BL Strom, KL Melmon - Pharmacoepidemiology, 2012 - Wiley Online Library
In order to be approved for marketing in the United States, drugs must be proven to be safe
and effective using “adequate and well‐controlled investigations.” This chapter clarifies the …
and effective using “adequate and well‐controlled investigations.” This chapter clarifies the …
Deleterious effects of reactive metabolites
SM Attia - Oxidative medicine and cellular longevity, 2010 - hindawi.com
A number of drugs have been withdrawn from the market or severely restricted in their use
because of unexpected toxicities that become apparent only after the launch of new drug …
because of unexpected toxicities that become apparent only after the launch of new drug …
Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system
CJ Henderson, LA McLaughlin, CR Wolf - Molecular pharmacology, 2013 - ASPET
We previously described the development of genetic models to study the in vivo functions of
the hepatic cytochrome P450 (P450) system, through the hepatic deletion of either …
the hepatic cytochrome P450 (P450) system, through the hepatic deletion of either …
Shortcomings in the clinical evaluation of new drugs: acute myeloid leukemia as paradigm
RB Walter, FR Appelbaum, MS Tallman… - Blood, The Journal …, 2010 - ashpublications.org
Drugs introduced over the past 25 years have benefitted many patients with acute myeloid
leukemia (AML) and provided cure for some. Still, AML remains difficult to treat, and most …
leukemia (AML) and provided cure for some. Still, AML remains difficult to treat, and most …
Functional cloning and characterization of antibiotic resistance genes from the chicken gut microbiome
W Zhou, Y Wang, J Lin - Applied and environmental microbiology, 2012 - Am Soc Microbiol
Culture-independent sampling in conjunction with a functional cloning approach identified
diverse antibiotic resistance genes for different classes of antibiotics in gut microbiomes from …
diverse antibiotic resistance genes for different classes of antibiotics in gut microbiomes from …
[HTML][HTML] Affordability of cancer care in the United Kingdom–is it time to introduce user charges?
A Aggarwal, R Sullivan - Journal of Cancer Policy, 2014 - Elsevier
Context In high income countries the costs of delivering high quality equitable care are
outstripping present budgets. This article reviews the affordability of cancer care in these …
outstripping present budgets. This article reviews the affordability of cancer care in these …
Synthesis of Cationic Antimicrobial β2,2-Amino Acid Derivatives with Potential for Oral Administration
We have prepared a series of highly potent achiral cationic β2, 2-amino acid derivatives that
fulfill the Lipinski's rule of five and that contain the basic structural requirements of short …
fulfill the Lipinski's rule of five and that contain the basic structural requirements of short …
Molecular networks in drug discovery
Despite the dramatic increase of global spending on drug discovery and development, the
approval rate for new drugs is declining, due chiefly to toxicity and undesirable side effects …
approval rate for new drugs is declining, due chiefly to toxicity and undesirable side effects …