Over the past decades, a multitude of experimental drugs have been shown to delay
disease progression in preclinical animal models of amyotrophic lateral sclerosis (ALS) but …

The evolution of clinical research traverses a long and fascinating journey. From the first
recorded trial of legumes in biblical times to the first randomized controlled of trial of …

Budd-Chiari syndrome (BCS) is a rare and potentially life-threatening disorder characterized
by obstruction of the hepatic outflow tract at any level between the junction of the inferior …

Report 3 is devoted to the history, nature, and limitations of the epidemiological criteria for
causality (“Hill's criteria”). Based on material from the original publications of leading …

Information technology is transforming the practices of medicine, nursing, and biomedical
research. Computers can now render diagnoses and prognoses more accurately than …

Translation of animal-based preclinical research is hampered by poor validity and
reproducibility issues. Unfortunately, preclinical research has 'fallen between the stools' of …

The fascinating journey of clinical research started early in 562 BC, when King
Nebuchadnezzar ordered his people to eat and drink only meat and wine since he believed …

In this article, I develop a critical view of the development and state of research ethics in
political science. The central problem is that political scientists have inappropriately followed …

Systematic experimentation is usually conceived as a practice that began with science, but
this assumption does not seem to be correct. Historical evidence gives us strong reasons to …

Medical history explains that Persian physicians used scientific methods based on clinical
experiences and observations for treatment from pre-Islamic time (before 637 AD) and …