Currently, medications used to treat rheumatoid arthritis (RA) are glucocorticoids (GCs) and
nonsteroidal anti‐inflammatory drugs (NSAIDs), predominantly used for controlling the pain …

With tens of thousands of plant species on earth, we are endowed with an enormous wealth
of medicinal remedies from Mother Nature. Natural products and their derivatives represent …

Background Post-thrombotic syndrome (PTS) is a common and burdensome complication of
deep venous thrombosis (DVT). Previous trials suggesting benefit of elastic compression …

Background Osteoarthritis (OA) is a common form of arthritis and is often associated with
significant disability and impaired quality of life. This is an update of a Cochrane review first …

Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Ibuprofen first came to market about 50 years ago and rapidly moved to over-the-counter
(OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health …

Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common
disorder in which the two main clinical features are pelvic pain and lower urinary tract …

The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-
inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was …

Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

Abstract Two new series of 1, 3, 4-oxadiazole and coumarin derivatives based on pyrimidine-
5-carbonitrile scaffold have been synthesized and evaluated for their COX-1/COX-2 …