Probiotics for the Prevention of Clostridium difficile–Associated Diarrhea: A Systematic Review and Meta-analysis

BC Johnston, SSY Ma, JZ Goldenberg… - Annals of internal …, 2012 - acpjournals.org
Background: Antibiotic treatment may disturb the resistance of gastrointestinal flora to
colonization. This may result in complications, the most serious of which is Clostridium …

Do NSAIDs, antibiotics, infections, or stress trigger flares in IBD?

S Singh, LA Graff, CN Bernstein - Official journal of the American …, 2009 - journals.lww.com
Non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, enteric or other systemic
infections, and stress have all been reported to be potential triggers of inflammatory bowel …

Increasing Risk of Relapse after Treatment of Clostridium difficile Colitis in Quebec, Canada

J Pépin, ME Alary, L Valiquette, E Raiche… - Clinical Infectious …, 2005 - academic.oup.com
Background Clinicians who treat patients with Clostridium difficile–associated diarrhea
(CDAD) in Quebec, Canada, have noted an apparent increase in the proportion of patients …

Human Hypervirulent Clostridium difficile Strains Exhibit Increased Sporulation as Well as Robust Toxin Production

M Merrigan, A Venugopal, M Mallozzi… - Journal of …, 2010 - Am Soc Microbiol
Toxigenic Clostridium difficile strains produce two toxins (TcdA and TcdB) during the
stationary phase of growth and are the leading cause of antibiotic-associated diarrhea. C …

Health Care-Associated Clostridium difficile Infection in Adults Admitted to Acute Care Hospitals in Canada: A Canadian Nosocomial Infection Surveillance Program …

D Gravel, M Miller, A Simor, G Taylor… - Clinical Infectious …, 2009 - academic.oup.com
Background. Clostridium difficile infection (CDI) is the most frequent cause of health care-
associated infectious diarrhea in industrialized countries. The only previous report …

Effect of a Fermented Milk Combining Lactobacillus Acidophilus CL1285 and Lactobacillus Casei in the Prevention of Antibiotic-Associated Diarrhea: A Randomized …

M Beausoleil, N Fortier, S Guénette… - Canadian Journal of …, 2007 - hindawi.com
BACKGROUND: Antibiotic-associated diarrhea is an important problem in hospitalized
patients. The use of probiotics is gaining interest in the scientific community as a potential …

Surface-Layer Protein A (SlpA) Is a Major Contributor to Host-Cell Adherence of Clostridium difficile

MM Merrigan, A Venugopal, JL Roxas, F Anwar… - PloS one, 2013 - journals.plos.org
Clostridium difficile is a leading cause of antibiotic-associated diarrhea, and a significant
etiologic agent of healthcare-associated infections. The mechanisms of attachment and host …

Probiotic therapy for the prevention and treatment of Clostridium difficile-associated diarrhea: a systematic review

N Dendukuri, V Costa, M McGregor, JM Brophy - Cmaj, 2005 - Can Med Assoc
Background: The recent increase in the number and severity of cases of nosocomial
Clostridium difficile-associated diarrhea (CDAD) has prompted interest in the use of …

Functional characterization of Clostridium difficile spore coat proteins

P Permpoonpattana, J Phetcharaburanin… - Journal of …, 2013 - Am Soc Microbiol
Spores of Clostridium difficile play a key role in the dissemination of this important human
pathogen, and until recently little has been known of their functional characteristics. Genes …

Analysis of Proline Reduction in the Nosocomial Pathogen Clostridium difficile

S Jackson, M Calos, A Myers, WT Self - Journal of bacteriology, 2006 - Am Soc Microbiol
Clostridium difficile, a proteolytic strict anaerobe, has emerged as a clinically significant
nosocomial pathogen in recent years. Pathogenesis is due to the production of lethal toxins …