A number of hierarchies of evidence have been developed to enable different research
methods to be ranked according to the validity of their findings. However, most have focused …

Objective: To revise and expand the 1996 Osteoporosis Society of Canada clinical practice
guidelines for the management of osteoporosis, incorporating recent advances in diagnosis …

Background Long-term microvascular and neurologic complications cause major morbidity
and mortality in patients with insulin-dependent diabetes mellitus (IDDM). We examined …

ContextMicroalbuminuria is a risk factor for cardiovascular (CV) events. The relationship
between the degree of albuminuria and CV risk is unclear. ObjectivesTo estimate the risk of …

Objective: To determine the relation between systolic blood pressure over time and the risk
of macrovascular or microvascular complications in patients with type 2 diabetes. Design …

OBJECTIVE—We sought to meta-analyze the effects of different modes of exercise training
on measures of glucose control and other risk factors for complications of diabetes …

Background Exercise is generally recommended for people with type 2 diabetes mellitus.
However, some studies evaluate an exercise intervention including diet or behaviour …

OBJECTIVE—The utility of rapid and reliable sensory tests appropriate for the diagnosis of
neuropathy in the diabetes clinic, rather than as prognostic tools for the prediction of foot …

All therapies currently recommended for the management of osteoporosis act mainly to
inhibit bone resorption and reduce bone remodeling. PTH and its analog, teriparatide …

A 60-year-old man with recently diagnosed type 2 diabetes mellitus has a serum creatinine
level of 1.5 mg per deciliter (133 μmol per liter), and a dipstick test shows proteinuria (++) …