Background. Alzheimer's disease (AD) is a progressive neurodegenerative disorder
affecting many individuals worldwide with no effective treatment to date. AD is characterized …

Previous studies have shown that β-amyloid (Aβ) peptides are neurotoxic. Recent data
suggest that neurons undergoing Aβ-induced cell death exhibit characteristics that …

Regional cerebral blood flow (CBF), oxygen extraction ratio (OER), oxygen utilization
(CMRO2) and blood volume (CBV) were measured in a group of 34 healthy volunteers (age …

To improvethe diagnosticperformanceof PET as an aid in
evaluatingpatientssuspectedofhawig@ 4Jzhalmer'sdisease, we devalopeda …

A recent demonstration of markedly reduced (‐50%) activity of cytochrome oxidase (CO;
complex 4), the terminal enzyme of the mitochondrial enzyme transport chain, in platelets of …

The purpose of this study was to confirm with pathologic verification 2 beliefs related to
Alzheimer's disease (AD):(a) the long-standing impression that bilateral temporo-parietal …

Nuclear magnetic resonance (NMR) imaging was employed to study 10 patients with
Alzheimer's disease (AD) and seven healthy elderly control subjects. Coronal sections were …

In order to determine the relationship between cognitive dysfunction and motor behavior in
older adults, 41 cognitively normal elderly (NL), 25 cases exhibiting mild cognitive …

Background Regional cerebral blood flow (CBF), a good indirect index of cerebral
pathologic changes in Alzheimer disease (AD), is more severely reduced in patients with …

Studies in animals and postmortem human brain tissue support a role for P-glycoprotein in
clearance of cerebral β-amyloid across the blood–brain barrier (BBB). We tested the …