Background Nausea and vomiting are the most common symptoms experienced in early
pregnancy, with nausea affecting between 70 and 85% of women. About half of pregnant …

This thoroughly revised and updated reference addresses the drugs and chemicals causing
malformations and congenital anomalies in the human fetus-comprehensively reviewing …

Objective: to review the extensive literature pertaining to the reproductive and teratogenic
effects of Bendectin and the opinions of the scientific experts for the defense and plaintiff …

This article presents a stepwise approach for conducting a meta-analysis of epidemiological
studies based on proposed guidelines. This systematic method is recommended for …

This study determined the advice reported to be received by women suffering from nausea
and vomiting of pregnancy (NVP) from their caregivers regarding management, the …

Beginning in the mid 1970s the manufacturer of Benedictin was sued repeatedly over
allegations that the drug--prescribed for pregnant women to overcome the effects of morning …

Cynomolgus monkeys, rhesus monkeys and baboons were administered 10 to 40 times the
human dose equivalent of Bendectin throughout the major period of organogenesis (22 (±3) …

We aimed to study the association between use of antihistamines in early pregnancy and
congenital heart defects (CHD) in the offspring. Design: Two case–control studies. Setting …

The embryotoxic and teratogenic potential of Bendectin was assessed in this double‐blind
study in the cynomolgus monkey (Macaca fascicularis). Bendectin was administered orally …

F or most of this century it has been believed that the placenta serves as a physical barrier
preventing extemal teratogens from reaching the developing embryo and fetus. The …