Although metformin has become a drug of choice for the treatment of type 2 diabetes
mellitus, some patients may not receive it owing to the risk of lactic acidosis. Metformin …

DIABETES MELLITUS IS A CHRONIC DISEASE that is growing in prevalence worldwide.
Pharmacologic therapy is often necessary to achieve optimal glycemic control in the …

Background Sulfonylurea drugs have been the only oral therapy available for patients with
non-insulin-dependent diabetes mellitus (NIDDM) in the United States. Recently, however …

OBJECTIVE Delayed-release metformin (Met DR) is formulated to deliver the drug to the
lower bowel to leverage the gut-based mechanisms of metformin action with lower plasma …

The effect of metformin on glucose metabolism was examined in eight obese (percent ideal
body weight, 151±9%) and six lean (percent ideal body weight, 104±4%) noninsulin …

Although metformin has been used for over 60 years, the balance between the drug's
beneficial and adverse effects is still subject to debate. Following an analysis of how cases …

Type 2 diabetes mellitus results from impaired insulin secretion and reduced peripheral
insulin sensitivity. Treatment options include diet, oral antihyperglycemic agents, and insulin …

The myocardium is capable of utilizing different energy substrates, which is referred to as
“metabolic flexibility.” This process assures ATP production from fatty acids, glucose, lactate …

OBJECTIVE To provide a context for the interpretation of lactic acidosis risk among patients
using metformin, we measured rates of lactic acidosis in patients with type 2 diabetes before …

Background: The usefulness of metformin as an oral antidiabetic agent is widely accepted.
However, several other classes of oral antidiabetic agents have been recently introduced …