Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …

Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …

Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …

Natural products provide an important source of pharmaceuticals and chemical tools.
Traditionally, assessment of unexplored microbial phyla has led to new natural products …

The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects
owing to increased patient compliance. Unfortunately, the oral delivery route is beset with …

Cyclosporin is a selective immunosuppressant that has a variety of applications in medical
practice. Like phenytoin and the calcium channel blockers, the drug is associated with …

Background Opening of the mitochondrial permeability transition pore is the underlying
cause of cellular dysfunction during diverse pathological situations. Although this …

Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …

Antibiotics have been a key part of clinical treatments for more than 70 years. Long-term use
of antimicrobial treatments has led to the development of severe bacterial resistance, which …

Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths
recorded each year. Among these, Candida infections are frequent in at-risk populations …