Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds
Freestanding nonproteinogenic amino acids have long been recognized for their
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …
antimetabolite properties and tendency to be uncovered to reactive functionalities by the …
Crystal structures of protein-bound cyclic peptides
Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …
confers key advantages such as protection from proteolytic degradation, altered solubility …
[HTML][HTML] Effects of apigenin on RBL-2H3, RAW264. 7, and HaCaT cells: anti-allergic, anti-inflammatory, and skin-protective activities
CH Park, SY Min, HW Yu, K Kim, S Kim, HJ Lee… - International Journal of …, 2020 - mdpi.com
Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …
Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus
Y Li, SR Lee, EJ Han… - Angewandte Chemie …, 2022 - Wiley Online Library
Natural products provide an important source of pharmaceuticals and chemical tools.
Traditionally, assessment of unexplored microbial phyla has led to new natural products …
Traditionally, assessment of unexplored microbial phyla has led to new natural products …
Polymeric micelles for oral drug delivery: Why and how
MF Francis, M Cristea, FM Winnik - Pure and Applied Chemistry, 2004 - degruyter.com
The oral delivery of drugs is regarded as the optimal means for achieving therapeutic effects
owing to increased patient compliance. Unfortunately, the oral delivery route is beset with …
owing to increased patient compliance. Unfortunately, the oral delivery route is beset with …
Cyclosporin and the gingival tissues
RA Seymour, DJ Jacobs - Journal of clinical periodontology, 1992 - Wiley Online Library
Cyclosporin is a selective immunosuppressant that has a variety of applications in medical
practice. Like phenytoin and the calcium channel blockers, the drug is associated with …
practice. Like phenytoin and the calcium channel blockers, the drug is associated with …
Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore
M Gutiérrez-Aguilar, CP Baines - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Background Opening of the mitochondrial permeability transition pore is the underlying
cause of cellular dysfunction during diverse pathological situations. Although this …
cause of cellular dysfunction during diverse pathological situations. Although this …
[HTML][HTML] How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances
A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …
substances that can have beneficial but also detrimental effects on human health. These so …
Repurposed drug candidates for antituberculosis therapy
Q An, C Li, Y Chen, Y Deng, T Yang, Y Luo - European journal of medicinal …, 2020 - Elsevier
Antibiotics have been a key part of clinical treatments for more than 70 years. Long-term use
of antimicrobial treatments has led to the development of severe bacterial resistance, which …
of antimicrobial treatments has led to the development of severe bacterial resistance, which …
[HTML][HTML] Azole potentiation in Candida species
JS Stenkiewicz-Witeska, IV Ene - PLoS Pathogens, 2023 - journals.plos.org
Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths
recorded each year. Among these, Candida infections are frequent in at-risk populations …
recorded each year. Among these, Candida infections are frequent in at-risk populations …