Evolution of blood-brain-barrier permeability after acute ischemic stroke

Z Merali, K Huang, D Mikulis, F Silver, A Kassner - PloS one, 2017 - journals.plos.org
The dynamics of BBB permeability after AIS in humans are not well understood. In the
present study we measured the evolution of BBB permeability after AIS in humans using MRI. …

Assessment of blood–brain barrier disruption in stroke

A Kassner, Z Merali - Stroke, 2015 - Am Heart Assoc
The blue azo dye, Evans blue, has a MW of 1.0 kDa. A notable property of Evans blue is its
propensity to bind serum albumin. The dye can, therefore, be used to measure the …

Using a machine learning approach to predict outcome after surgery for degenerative cervical myelopathy

ZG Merali, CD Witiw, JH Badhiwala, JR Wilson… - PloS one, 2019 - journals.plos.org
Degenerative cervical myelopathy (DCM) is a spinal cord condition that results in progressive
non-traumatic compression of the cervical spinal cord. Spine surgeons must consider a …

A deep learning model for detection of cervical spinal cord compression in MRI scans

Z Merali, JZ Wang, JH Badhiwala, CD Witiw… - Scientific reports, 2021 - nature.com
Magnetic Resonance Imaging (MRI) evidence of spinal cord compression plays a central role
in the diagnosis of degenerative cervical myelopathy (DCM). There is growing recognition …

Deep sequential learning for cervical spine fracture detection on computed tomography imaging

…, MT Arciniegas, Z Merali… - 2021 IEEE 18th …, 2021 - ieeexplore.ieee.org
Fractures of the cervical spine are a medical emergency and may lead to permanent paralysis
and even death. Accurate diagnosis in patients with suspected fractures by computed …

Longitudinal assessment of imatinib's effect on the blood–brain barrier after ischemia/reperfusion injury with permeability MRI

Z Merali, J Leung, D Mikulis, F Silver… - Translational stroke …, 2015 - Springer
Acute ischemic stroke (AIS) often results in degeneration of the blood–brain barrier (BBB),
which can lead to vasogenic edema and an increased risk of intracerebral hemorrhage. …

Predicting outcomes after surgical decompression for mild degenerative cervical myelopathy: moving beyond the mJOA to identify surgical candidates

JH Badhiwala, LD Hachem, Z Merali, CD Witiw… - …, 2020 - journals.lww.com
BACKGROUND Patients with mild degenerative cervical myelopathy (DCM) represent a
heterogeneous population, and indications for surgical decompression remain controversial. …

Patient phenotypes associated with outcome following surgery for mild degenerative cervical myelopathy: a principal component regression analysis

…, F Nassiri, BNR Jaja, MA Akbar, A Mansouri, Z Merali… - The Spine Journal, 2018 - Elsevier
Background Context Predictors of outcome after surgery for degenerative cervical myelopathy
(DCM) have been determined previously through hypothesis-driven multivariate statistical …

Explanatory versus pragmatic trials: an essential concept in study design and interpretation

Z Merali, JR Wilson - Clinical spine surgery, 2017 - journals.lww.com
Randomized clinical trials often represent the highest level of clinical evidence available to
evaluate the efficacy of an intervention in clinical medicine. Although the process of …

Gender-based differences in physician payments within the fee-for-service system in Ontario: a retrospective, cross-sectional study

Z Merali, AK Malhotra, M Balas, GR Lorello, A Flexman… - CMAJ, 2021 - Can Med Assoc
Background: Differences in physician income by gender have been described in numerous
jurisdictions, but few studies have looked at a Canadian cohort with adjustment for …