OBJECTIVES: Several studies have raised concern regarding the possible association
between proton-pump inhibitors (PPIs) andClostridium difficileinfection (CDI). We aimed to …

Background There is growing evidence that sleep duration and quality may be associated
with cardiovascular harm and mortality. Methods and Results We conducted a systematic …

RESEARCH Page 1 RESEARCH Comparative cardiovascular effects of thiazolidinediones:
systematic review and meta-analysis of observational studies Yoon Kong Loke, senior …

Objectives: To assess the incidence of gastrointestinal haemorrhage associated with long
term aspirin therapy and to determine the effect of dose reduction and formulation on the …

AIMS: Recent studies have suggested an increased risk of fractures with proton pump
inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs). We planned to perform a meta-…

Background Decisions on treatment are guided, not only by the potential for benefit, but also
by the nature and severity of adverse drug reactions. However, some researchers have …

Background Data from pharmacokinetic and pharmacodynamic studies indicate that the
adverse clopidogrel – proton pump inhibitor (PPI) interaction may vary between PPIs, with …

Background: Bisphosphonates are widely used in osteoporosis, but there have been concerns
about a potential link between bisphosphonate therapy and atrial fibrillation. Objective: …

Background Long-term inhaled corticosteroids (ICS) may reduce growth velocity and final
height of children with asthma. We aimed to evaluate the association between ICS use of >12 …

Background In 2016, the World Health Organization (WHO) strongly recommended the use
of a high fraction of inspired oxygen (FiO 2 ) in adult patients undergoing general …