2020 will go down in history as the year when the global community was awakened to the
fragility of human health and the interdependence of the ecosystem, economy, and humanity. …

Fetal programming associated with in utero exposure to maternal stress is thought to alter
gene expression, resulting in phenotypes that promote survival in a pathogen-rich and nutrient-…

A significant proportion of patients with type 2 diabetes mellitus have a low testosterone level
relative to reference ranges based on healthy young men. Only a small number of these …

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases
and controls, and we found that a previously described variant in the transcription factor 7-…

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is
characterized by chaotic electrical activity of the atria 1 . It affects one in ten individuals over the …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …

We carried out a multistage genome-wide association study of type 2 diabetes mellitus in
Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The …

We performed a genome-wide association scan to search for sequence variants conferring
risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. …

We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D)
in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-…