The regulatory T (Treg) cells restrain immune responses through suppressor-function
elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical …

Background: Hyperglycemia is associated with increased mortality in critically ill patients.
Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality …

This review of leukotrienes, which are lipid mediators with a broad array of clinical effects,
and leukotriene receptors considers the biochemical and physiological aspects of these …

Objective: To review the biochemistry and biological activities of leukotrienes, focusing on
their role in the mediation of inflammatory diseases. Data Sources: MEDLINE (1966-1994), …

Airway inflammation and remodeling in chronic asthma are characterized by airway
eosinophilia, hyperplasia of goblet cells and smooth muscle, and subepithelial fibrosis. We …

A family of beta-galactoside-binding animal lectins has recently been designated as
galectins. One member of this family, galectin-3, has been known as epsilon BP for its IgE-binding …

Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a ravaging condition of
progressive lung scarring and destruction. Anti-inflammatory therapies including corticosteroids …

A new paradigm for asthma pathogenesis is presented in which exaggerated inflammation
and remodeling in the airways are a consequence of abnormal injury and repair responses …

The synthesis of a new retinoid, N-(4-hydroxyphenyl)-all-trans-retinamide, which has useful
biological properties, is described. This retinoid was more potent than retinyl acetate in …

Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways
and increased bronchial hyperreactivity as are observed in human asthma. We employed …