Background Data from prospective cohort studies regarding the association between subclinical
hyperthyroidism and cardiovascular outcomes are conflicting. We aimed to assess the …

Background: Atrial fibrillation (AF) is a highly prevalent disorder leading to heart failure, stroke,
and death. Enhanced understanding of modifiable risk factors may yield opportunities for …

Objective: The objective was to determine the risk of stroke associated with subclinical
hypothyroidism. Data Sources and Study Selection: Published prospective cohort studies were …

Context Data regarding the association between subclinical hypothyroidism and cardiovascular
disease outcomes are conflicting among large prospective cohort studies. This might …

Background— American College of Cardiology/American Heart Association guidelines for
the diagnosis and management of heart failure recommend investigating exacerbating …

Background The use of levothyroxine to treat subclinical hypothyroidism is controversial. We
aimed to determine whether levothyroxine provided clinical benefits in older persons with …

Objectives To investigate the performance of classic risk factors, and of some new biomarkers,
in predicting cardiovascular mortality in very old people from the general population with …

Importance Associations between subclinical thyroid dysfunction and fractures are unclear
and clinical trials are lacking. Objective To assess the association of subclinical thyroid …

… data; Wendy den Elzen and Jacobijn Gussekloo drafted the manuscript; Wendy den Elzen,
… Jacobijn Gussekloo supervised the study; Wendy den Elzen, Anton de Craen and Jacobijn …

Introduction In 2008, the Ministry of Health, Welfare and Sport commissioned the National
Care for the Elderly Programme. While numerous research projects in older persons’ health …