Human liver preparations were used to screen various drugs for their capability of binding to
mephenytoin p-hydroxylase and sparteine monooxygenase, two cytochrome P-450-…

Ranitidine, an H 2 ‐receptor antagonist, has been shown to reduce pentagastrin‐stimulated
gastric secretion. We examined the relationship between inhibition of gastric secretion and …

Genetic deficiencies in the oxidative metabolism of sparteine and debrisoquine in man are
well documented (Eichelbaum, 1984; Kalow, 1984). Poor metabolizers of sparteine and …

AS a result of improvements in treatment of the bleeding, infections and coma complicating
severe liver disease it has become relatively common for patients with cirrhosis to die in a …

WA MAHON, FRCP [C], J. HOLLAND, MD and MB UROWITZ, MD, Toronto fT\HE clinical
syndrome of diabetic ketoacidosis-*¦ and its therapy have been long known and are familiar to …

… THE IN VIVO EFFECTS OF ADRENERGIC STIMULATION AND BLOCKADE ON THE
HUMAN UTERUS AT TERM’ MAHON, DWJ … wa.s increased … MAHON ET AL. …

Gentamicin toxicity has been shown to be related to high concentrations in serum. Because
there is a narrow range between its therapeutic and toxic levels, serial monitoring of …

Previous studies suggest that antacids are more effective than intravenous cimetidine in
maintaining the gastric pH above 4.0 in acutely ill patients. We hypothesized that this was …

… MAHON, MD, FRCP[C],J Toronto … Mahon, Clinical Pharma¬ cology Laboratory,
Toronto General Hospital, 101 College Street, Toronto 2, Ontario. …

Over 40 published and unpublished articles on double-blind controlled clinical trials with the
local application of benzydamine as an antiinflammatory drug were reviewed with special …