Chronic catheterization of the spinal subarachnoid space
TL Yaksh, TA Rudy - Physiology & behavior, 1976 - Elsevier
To administer drugs into the spinal subarachnoid space of unanesthetized and intact rats
and rabbits, a procedure is described whereby a polyethylene catheter (PE-10) may be …
and rabbits, a procedure is described whereby a polyethylene catheter (PE-10) may be …
Analgesia mediated by a direct spinal action of narcotics
TL Yaksh, TA Rudy - Science, 1976 - science.org
Narcotic analgetics administered directly into the spinal subarachnoid space of the rat via a
chronically inserted catheter produce a potent analgesia that can be antagonized by …
chronically inserted catheter produce a potent analgesia that can be antagonized by …
Upregulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats
…, KA Stauderman, ME Williams, TL Yaksh - Journal of …, 2001 - Soc Neuroscience
Peripheral nerve injury can lead to a persistent neuropathic pain state in which innocuous
tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the …
tactile stimulation elicits pain behavior (tactile allodynia). Spinal administration of the …
Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.
AB Malmberg, TL Yaksh - Journal of Pharmacology and Experimental …, 1992 - ASPET
Subcutaneous injection of formalin into the dorsal surface of the hindpaw evoked a two-phased
flinching (phase 1:0-9 min; phase 2: 10-60 min) of the injected paw. Intrathecal …
flinching (phase 1:0-9 min; phase 2: 10-60 min) of the injected paw. Intrathecal …
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino …
TL Yaksh - Pain, 1989 - Elsevier
… and Yaksh, TL, In viva studies on spinal opiate receptor … 60 Yaksh, TL, Inhibition by etorphine
of the discharge of dorsal horn neurons: effects upon the neuronal response to both high- …
of the discharge of dorsal horn neurons: effects upon the neuronal response to both high- …
Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing
TL Yaksh - Pharmacology Biochemistry and Behavior, 1985 - Elsevier
Spinopetal pathways may be activated by a variety of brainstem manipulations including
microinjections of morphine which are known to modulate spinal nociceptive processing. Based …
microinjections of morphine which are known to modulate spinal nociceptive processing. Based …
Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques
TL Yaksh, TA Rudy - Pain, 1977 - journals.lww.com
Narcotics reduce the behavioral response to injury, while leaving unaffected the response
to other stimuli. This effect could be due to a reduction of the central transmission of injury …
to other stimuli. This effect could be due to a reduction of the central transmission of injury …
Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray
TL Yaksh, JC Yeung, TA Rudy - Brain research, 1976 - Elsevier
An extensive mapping of the rat brain (403 sites) ranging from AP +8 to AP −3 revealed that
the region showing maximum sensitivity to the intracerebral administration of morphine in …
the region showing maximum sensitivity to the intracerebral administration of morphine in …
Spinal opiate analgesia: characteristics and principles of action
TL Yaksh - Pain, 1981 - journals.lww.com
The iontophoretic administration of opiates onto dorsal h:? rn nc~ urons (2, 14, 37, 49,153,227,229]
afld particularly into their drndtitic arboriaation in the substantia gelatinosa will inhibit …
afld particularly into their drndtitic arboriaation in the substantia gelatinosa will inhibit …
In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa …
C Schmauss, TL Yaksh - Journal of Pharmacology and Experimental …, 1984 - ASPET
The intrathecal administration of mu (morphine) and delta (D-Ala2-D-Leu5-enkephalin) but
not kappa agonists (ethylketocyclazocine, bremazocine and U50488H) or partial agonists (…
not kappa agonists (ethylketocyclazocine, bremazocine and U50488H) or partial agonists (…