Context Between March and July 2009, the largest number of confirmed cases of 2009
influenza A(H1N1) infection occurred in North America. Objective To describe characteristics, …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Objectives We examined the relationship between dominant sedation strategy, risk of delirium
and patient-centred outcomes in adults admitted to intensive care units (ICUs). Design …

ContextIncreasing contact has been reported between physicians and the pharmaceutical
industry, although no data exist in the literature regarding potential financial conflicts of …

Background Physicians' financial relationships with the pharmaceutical industry are controversial
because such relationships may pose a conflict of interest. It is unknown to what extent …

ContextHospital infection control policies that use patient isolation prevent nosocomial
transmission of infectious diseases, but may inadvertently lead to patient neglect and errors.…

Background: Frailty is a multidimensional syndrome characterized by loss of physiologic
and cognitive reserves that confers vulnerability to adverse outcomes. We determined the …

Background: The “To Err is Human” report published by the Institute of Medicine (IOM) in 1999
called for a national effort to make health care safer. Although the report has been widely …

PURPOSE: A small number of physicians generate a disproportionate share of complaints
from patients and of malpractice lawsuits. If these grievances relate to patients’ dissatisfaction …

Objective: To systematically review clinical practice guidelines (CPGs) for pediatric multisystem
trauma, appraise their quality, synthesize the strength of recommendations and quality of …