The obesity epidemic has led to an increased incidence of nonalcoholic fatty liver disease (NAFLD)
and type 2 diabetes. AMP-activated protein kinase (Ampk) regulates energy …

In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively
in adipocytes 1 . Adipose-specific knockout or overexpression of Glut4 alters systemic …

Rationale: Cardiovascular physiology and pathophysiology vary dramatically over the course
of the day. For example, myocardial infarction onset occurs with greater incidence during …

Lysosomes are the main proteolytic compartments of mammalian cells comprising of a
battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular …

Doxorubicin (DOX)-induced cardiotoxicity has been a well-known phenomenon to clinicians
and scientists for decades; however, molecular mechanisms underlying DOX cardiotoxicity …

Oxidative stress due to excessive reactive oxygen species (ROS) and depleted antioxidants
such as glutathione (GSH) can give rise to apoptotic cell death in acutely diabetic hearts and …

Aims/hypothesis Obesity is characterised by lipid accumulation in skeletal muscle, which
increases the risk of developing insulin resistance and type 2 diabetes. AMP-activated protein …

Emerging evidence suggests that impaired regulation of adipocyte lipolysis contributes to
the proinflammatory immune cell infiltration of metabolic tissues in obesity, a process that is …

The microphthalmia family (MITF, TFEB, TFE3, and TFEC) of transcription factors is emerging
as global regulators of cancer cell survival and energy metabolism, both through the …

Doxorubicin (DOX) is an effective anti-cancer agent. However, DOX treatment increases
patient susceptibility to dilated cardiomyopathy. DOX predisposes cardiomyocytes to insult by …