The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types that …

Innate immunity is the first line of defense against infectious microorganisms. The innate
immune system relies on germ line-encoded pattern recognition receptors (PRRs) to recognize …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

We have stably transformed mammalian cells with precisely defined procaryotic and
eucaryotic genes for which no selective criteria exist. The addition of a purified viral thymidine …

We present a procedure for eucaryotic structural gene isolation which involves the construction
and screening of cloned libraries of genomic DNA. Large random DNA fragments are …

Transcriptional activation of the interferon-β (IFN-β) gene requires assembly of an enhanceosome
containing ATF-2/c-Jun, IRF-3/IRF-7, and NFκB. These factors bind cooperatively to …

Virus infection, double-stranded RNA, and lipopolysaccharide each induce the expression
of genes encoding IFN-α and -β and chemokines, such as RANTES (regulated on activation, …

The expansion in the range and use of cloning techniques is reflected in the growth of this
classic manual from 1 to 3 volumes. The comb-bound large print format (with clear illustrations…

Ubiquitin-dependent proteolysis by the proteasome plays an essential role in a number of
key biological processes, including cell cycle progression, transcription, and signal …

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …