Background Hyponatremia is common among inpatients and is associated with severe
adverse outcomes such as osmotic demyelination syndrome. Current guidelines recommend …

Importance Scalable deprescribing interventions may reduce polypharmacy and the use of
potentially inappropriate medications (PIMs); however, few studies have been large enough …

Objectives To assess the effectiveness of prone positioning to reduce the risk of death or
respiratory failure in non-critically ill patients admitted to hospital with covid-19. Design …

Background Osmotic demyelination syndrome (ODS) is a rare but potentially devastating
neurologic complication of hyponatremia. The primary objective of this study was to identify the …

Background Overcorrection of plasma sodium in severe hyponatremia is associated with
osmotic demyelination syndrome. Desmopressin (DDAVP) can prevent overcorrection of …

Results A total of 623 patients presented with severe hyponatremia (mean initial value 112
mmol/L; SD 3.2). The prevalence of no, unlikely, possible, and definite overcorrection was 72…

• When considering how to structure medical care teams, it is important to consider how rapidly
teams can be scaled to need, their ability to integrate redeployed physicians and ensure …

… MacMillan’s work is supported financially by a fellowship from the HoPingKong Centre for …
TE MacMillan’s work is supported financially by a fellowship from the HoPingKong Centre for …

Background Hospital admissions provide an opportunity to deprescribe ineffective medications
and reduce pill burden. Docusate sodium is a stool softener that is frequently prescribed …

In this narrative review, we describe what is known about non-pharmacological and
pharmacological treatments for insomnia in medical inpatients, with a focus on melatonin. Hospital-…