Lack of a small animal model of the human hepatitis C virus (HCV) has impeded development
of antiviral therapies against this epidemic infection. By transplanting normal human …

Background— Glutaraldehyde fixation (GF) decreases but likely does not eliminate the
antigenicity of bioprosthetic heart valves. Rejection (with secondary dystrophic calcification) may …

HLA-B27 transgenic rats develop spontaneous colitis under specific pathogen-free conditions
(SPF) but germ-free rats remain disease-free, emphasizing a role for intestinal bacteria in …

The objective of the present investigation was to evaluate the effects of acidic pH of the perfusate
and presence of lipopolysaccharide (LPS) on permeability of rumen and colon mucosal …

Rodent models have been essential to understanding the immune‐mediated failure of aortic
valve allografts (AVAs). Decellularization has been proposed to reduce the immunogenicity …

Background A significant number of patients use opioids prior to total joint arthroplasty (TJA)
in North America and there is growing concern that preoperative opioid use negatively …

Colonic epithelial cells are constantly exposed to high levels of bacterial DNA in the intestinal
lumen and must recognize and respond appropriately to pathogens, while they maintain a …

Wood frogs, Rana sylvatica, tolerate the loss of 50-60% of total body water during experimental
dehydration. The rate of water loss for unprotected frogs is the same whether animals are …

Hatchlings of the painted turtle (Chrysemys picta marginata) are unique as the only reptile
and highest vertebrate life form known to tolerate the natural freezing of extracellular body …

OBJECTIVES: Cryopreserved valve allografts used in congenital cardiac surgery are
associated with a significant cellular and humoral immune response. This might be reduced by …