The article discusses the clinical cases of patients who developed red meat allergy after
experiencing tick bits in Sydney, New South Wales. Between 2003 and 200, 25 patients …

Rationale: Genetic variation influences susceptibility to clinical tuberculosis (TB). Activation
of the P2X 7 receptor on human macrophages induces killing of mycobacteria. We have …

The P2X 7 receptor is a ligand-gated cation channel that is highly expressed on mononuclear
leukocytes and that mediates ATP-induced apoptosis and killing of intracellular pathogens…

Protective immunity to mycobacterial infections requires activation of the antibacterial
mechanisms of infected macrophages. It has previously been reported that ATP treatment of …

Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction
and is caused by drugs in >90% of cases. It is rare, with an incidence of 1–5 patients per …

The mortality rate of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)
is high; approximately 5% for SJS and 25% for TEN. It is therefore vital for the treating …

Mycobacterial disease remains a serious global health problem. Tuberculosis causes more
than 2 million deaths a year, and leprosy is still a cause of severe disability in many parts of …

Drug reaction with eosinophilia and systemic symptoms ( DRESS ), also known as drug‐induced
hypersensitivity syndrome ( DIHS ), is a rare, severe cutaneous adverse reaction …

BackgroundStimulation of the P2X 7 purinergic receptor (P2X 7 ) in bacille Calmette-Guérin
(BCG)–infected human macrophages with extracellular adenosine triphosphate (ATP) leads …

Background Nonprescription of penicillin-containing antibiotics in patients diagnosed with
penicillin allergy is associated with morbidity and mortality. Adverse reactions to penicillins …