Mest (also known as Peg1), an imprinted gene expressed only from the paternal allele during
development, was disrupted by gene targeting in embryonic stem (ES) cells. The targeted …

Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia,
mainly characterized by round-headed spermatozoa that lack an acrosome. It originates …

Background Ex vivo manufacture of red blood cells from stem cells is a potential means to
ensure an adequate and safe supply of blood cell products. Advances in somatic cell …

The invariant chain (ii) has aroused much interest because of its close association with
major histocompatibiiity complex (MHC) class ii molecules. Various functions have been …

An increasing number of couples require medical assistance to achieve a pregnancy, and
more than 2% of the births in Western countries now result from assisted reproductive …

Globozoospermia, characterized by round-headed spermatozoa, is a rare (< 0.1% in male
infertile patients) and severe teratozoospermia consisting primarily of spermatozoa lacking an …

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES)
cells. Here, we reveal that an essential impact of this process is the protection of cellular …

Friedreich’s ataxia (FRDA) is a recessive neurodegenerative disorder commonly associated
with hypertrophic cardiomyopathy. FRDA is due to expanded GAA repeats within the first …

Infertility is a global healthcare problem, and despite long years of assisted reproductive
activities, a significant number of cases remain idiopathic. Our currently restricted understanding …

The sixth report of the ESHRE PGD Consortium is presented, relating to cycles collected for
the calendar year 2003 and follow-up of the pregnancies and babies born up to October …