A new wave of portable biosensors allows frequent measurement of health-related physiology.
We investigated the use of these devices to monitor human physiological changes during …

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its
early disease stages, its effects on biological processes or the transition to clinical T2D. To …

Precision health relies on the ability to assess disease risk at an individual level, detect early
preclinical conditions and initiate preventive strategies. Recent technological advances in …

Advances in omics technologies now allow an unprecedented level of phenotyping for
human diseases, including obesity, in which individual responses to excess weight are …

The diagnostic yield of exome sequencing (ES) has primarily been evaluated in individuals
of European ancestry, with less focus on underrepresented minority (URM) and underserved …

Recent advances in induced pluripotent stem cell (iPSC) technology and directed differentiation
of iPSCs into cardiomyocytes (iPSC-CMs) make it possible to model genetic heart …

Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in over 400
cellular reactions. During embryogenesis, mammals synthesize NAD de novo from dietary l ‐…

The use of genome‐scale sequencing allows for identification of genetic findings beyond
the original indication for testing (secondary findings). The ClinGen Actionability Working …

Purpose Somatic variants in tumor necrosis factor receptor–associated factor 7 (TRAF7) cause
meningioma, while germline variants have recently been identified in seven patients with …

Chromatin is essentially an array of nucleosomes, each of which consists of the DNA double-stranded
fiber wrapped around a histone octamer. This organization supports cellular …