Background Propofol is increasingly used for sedation during colonoscopy, with many recent
reports of randomised controlled trials (RCTs) and large non‐randomized case series. …

Background Standing balance deficits are common in individuals after stroke. One way to
address these deficits is to provide the individual with feedback from a force platform while …

Background Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid
resuscitation, yet controversy exists about their impact on kidney function. Objectives To …

Type 1 diabetes (T1D) in children results from autoimmune destruction of pancreatic beta
cells, leading to insufficient production of insulin 1 . A number of genetic determinants of T1D …

Background Type 2 diabetes mellitus is increasingly being observed among children and
youth, including the Native population of Canada. Only one study has investigated prenatal …

OBJECTIVE—Two recent genome-wide association (GWA) studies have revealed novel loci
for type 1 diabetes, a common multifactorial disease with a strong genetic component. To …

Background Gastro‐esophageal reflux (GER) is the refluxing of gastric contents into the
esophagus. Fifty per cent of all infants 0 to 3 months regurgitate at least once a day. This drops …

OBJECTIVE—In stage 1 of our genome-wide association (GWA) study for type 1 diabetes,
one locus at 16p13 was detected (P = 1.03 × 10 −10 ) and confirmed in two additional cohorts. …

The objective of this study was to determine the risk of death and potential for prevention of
mortality in a large population of children with growth hormone deficiency (GHD). The …

Background: The 2′,5′-oligoadenylate synthetase genes (OAS1, OAS2, and OAS3) map
to human chromosome 12q24 and encode a family of enzymes pivotal to innate antiviral …