[HTML][HTML] Human papillomavirus, vaccines and women's health: questions and cautions

A Lippman, R Melnychuk, C Shimmin, M Boscoe - Cmaj, 2007 - Can Med Assoc
CMAJ• August 28, 2007• 177 (5) 485 about 70% of infected women, and within 2 years for
90%. 7 Thus, HPV infection and cervical cancer must not be conflated: cervical cancer will not …

[HTML][HTML] Human cytomegalovirus chemokine receptor US28-induced smooth muscle cell migration is mediated by focal adhesion kinase and Src

DN Streblow, J Vomaske, P Smith, R Melnychuk… - Journal of Biological …, 2003 - ASBMB
The human cytomegalovirus-encoded chemokine receptor US28 induces arterial smooth
muscle cell (SMC) migration; however, the underlying mechanisms involved in this process are …

Human cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth muscle cell migration through Gα12

RM Melnychuk, DN Streblow, PP Smith… - Journal of …, 2004 - Am Soc Microbiol
Coupling of G proteins to ligand-engaged chemokine receptors is the paramount event in G-protein-coupled
receptor signal transduction. Previously, we have demonstrated that the …

[HTML][HTML] Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type–specific motility

J Vomaske, RM Melnychuk, PP Smith, J Powell… - PLoS …, 2009 - journals.plos.org
While most chemokine receptors fail to cross the chemokine class boundary with respect to
the ligands that they bind, the human cytomegalovirus (HCMV)-encoded chemokine receptor …

Mouse cytomegalovirus M33 is necessary and sufficient in virus-induced vascular smooth muscle cell migration

RM Melnychuk, P Smith, CN Kreklywich… - Journal of …, 2005 - Am Soc Microbiol
Mouse cytomegalovirus (MCMV) encodes two potential seven-transmembrane-spanning
proteins with homologies to cellular chemokine receptors, M33 and M78. While these virus-…

[HTML][HTML] Pandemic triage: the ethical challenge

RM Melnychuk, NP Kenny - Cmaj, 2006 - Can Med Assoc
Stand on Guard for Thee; however, without a carefully contemplated strategy of public
engagement, public education and trust may be difficult to capture when we need it most. In the …

When is it permissible to dismiss a family who refuses vaccines? Legal, ethical and public health perspectives

B Halperin, R Melnychuk, J Downie… - Paediatrics & child …, 2007 - academic.oup.com
Although immunization is one of the most important health interventions of the 20th century,
cases of infectious disease continue to occur. There are parents who refuse immunization for …

[HTML][HTML] HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase

J Vomaske, S Varnum, R Melnychuk, P Smith… - Herpesviridae, 2010 - Springer
Background Human Cytomegalovirus (HCMV) has been implicated in the acceleration of
vascular disease and chronic allograft rejection. Recently, the virus has been associated with …

The promise of public health: ethical reflections

NP Kenny, RM Melnychuk, Y Asada - Canadian journal of public health, 2006 - Springer
Public health is in the spotlight of public and political concern, providing a unique window of
opportunity for its revitalization and restoration as a pillar of the Canadian health care system…

Population and public health ethics in Canada: a snapshot of current national initiatives and future issues

SM Viehbeck, R Melnychuk, CW McDougall… - Canadian Journal of …, 2011 - Springer
To date, some work has been undertaken to define a code and stewardship framework for
public health ethics. However, gaps in our understanding and application of ethics to the field …