Background: Epidemiologically, high-density lipoprotein (HDL) cholesterol levels associate
inversely with risk of ischemic cardiovascular disease. Whether this is a causal relation is …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background High plasma levels of nonfasting triglycerides are associated with an increased
risk of ischemic cardiovascular disease. Whether lifelong low levels of nonfasting …

Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …

SARS-CoV-2 vaccines are crucial in controlling COVID-19, but knowledge of which factors
determine waning immunity is limited. We examined antibody levels and T-cell gamma-…

Objectives : The aim of this study was to test the hypothesis that elevated nonfasting remnant
cholesterol is a causal risk factor for ischemic heart disease independent of reduced high-…

We screened variants on an exome-focused genotyping array in> 300,000 participants (replication
in> 280,000 participants) and identified 444 independent variants in 250 loci …

Context Low levels of high-density lipoprotein (HDL) cholesterol are inversely related to
cardiovascular risk. Whether this is a causal effect is unclear. Objective To determine whether …

Aims Elevated non-fasting triglycerides mark elevated levels of remnant cholesterol. Using
a Mendelian randomization approach, we tested whether genetically increased remnant …

Background The appropriate oxygenation target for mechanical ventilation in comatose survivors
of out-of-hospital cardiac arrest is unknown. Methods In this randomized trial with a 2-by…