Objective To evaluate the relation between adherence to drug therapy, including placebo,
and mortality. Design Meta-analysis of observational studies. Data sources Electronic …

Methods Our objective was to assess the validity and reliability of the Edmonton Frail Scale (EFS)
in a sample referred for CGA (Table 1). All patients aged 65+ years were approached …

Atrial fibrillation (AF) is a growing public health problem associated with significant morbidity
and mortality. Numerous randomized controlled trials of warfarin have conclusively …

Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis,
assessment, prevention, and treatment of hypertension in adults and children. This year, …

Heart failure remains a common diagnosis, especially in older individuals. It continues to be
associated with significant morbidity and mortality, but major advances in both diagnosis …

OBJECTIVE—Metformin is considered contraindicated in patients with heart failure because
of concerns over lactic acidosis, despite increasing evidence of potential benefit. The aim of …

Hypertension Canada’s 2020 guidelines for the prevention, diagnosis, risk assessment, and
treatment of hypertension in adults and children provide comprehensive, evidence-based …

Background Phosphate binders (calcium-based and calcium-free) are recommended to
lower serum phosphate and prevent hyperphosphataemia in patients with chronic kidney …

Objective To review the literature on the association between antidiabetic agents and morbidity
and mortality in people with heart failure and diabetes. Design Systematic review and …

Background: Frailty is a multidimensional syndrome characterized by loss of physiologic
and cognitive reserves that confers vulnerability to adverse outcomes. We determined the …