The Health Utilities Index Mark 2 (HUI: 2) is a generic multiattribute, preference-based
system for assessing health-related quality of life. Health Utilities Index Mark 2 consists of two …

The Dana-Farber Cancer Institute (DFCI) acute lymphoblastic leukemia (ALL) Consortium
Protocol 91-01 was designed to improve the outcome of children with newly diagnosed ALL …

This paper reviews the Health Utilities Index (HUI? systems as means to describe health status
and obtain utility scores reflecting health-related quality of life (HRQoL). The HUI Mark 2 (…

Background Doxorubicin chemotherapy is very effective in children with acute lymphoblastic
leukemia (ALL) but also injures myocardial cells. Dexrazoxane, a free-radical scavenger, …

The overall cure rate for cancer in childhood now exceeds 70% and is projected to reach 85%
by the year 2010 in industrialized countries. Therefore, major attention is being placed on …

Importance Although cancer remains the most common cause of disease-related death in
adolescents and young adults (AYAs) in high-income countries, their overall survival rates …

The Dana-Farber Cancer Institute (DFCI) acute lymphoblastic leukemia (ALL) Consortium
has been conducting multi-institutional clinical trials in childhood ALL since 1981. The …

BACKGROUND With prior reports indicating a lack of progress in survival improvement in
older adolescents and young adults (AYAs) aged 15 to 39 years with cancer compared with …

We estimate that there will be 13·7 million new cases of childhood cancer globally between
2020 and 2050. At current levels of health system performance (including access and referral…

Children with acute lymphoblastic leukemia (ALL) often develop bone pain, abnormal gait,
and unusual fractures while in remission and receiving continuing chemotherapy. A …