User profiles for Richard P. Bazinet

Richard P Bazinet

University of Toronto
Verified email at utoronto.ca
Cited by 13068

Polyunsaturated fatty acids and their metabolites in brain function and disease

RP Bazinet, S Layé - Nature reviews neuroscience, 2014 - nature.com
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids (PUFAs)
arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet - Pharmacological reviews, 2018 - ASPET
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes. Over …

Supplementation of Conventional Therapy With the Novel Grain Salba (Salvia hispanica L.) Improves Major and Emerging Cardiovascular Risk Factors in Type 2 …

…, AL Jenkins, AL Rogovik, RP Bazinet… - Diabetes …, 2007 - Am Diabetes Assoc
OBJECTIVE—To determine whether addition of Salba (Salvia hispanica L.), a novel whole
grain that is rich in fiber, α-linolenic acid (ALA), and minerals to conventional treatment is …

[HTML][HTML] Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

AF Domenichiello, AP Kitson, RP Bazinet - Progress in lipid research, 2015 - Elsevier
Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly
from the diet or synthesized in the body from α-linolenic acid (ALA). Debate exists as to …

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: an in situ cerebral perfusion study

…, F Bourasset, S Oddo, F LaFerla, RP Bazinet… - Neurochemistry …, 2009 - Elsevier
Docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids are n-3 polyunsaturated fatty
acids with a therapeutic potential for CNS diseases. Here, using an in situ brain perfusion …

[HTML][HTML] Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: a systematic review and meta-analysis of randomized …

…, LA Leiter, PM Kris-Etherton, V Vuksan, RP Bazinet… - Cmaj, 2014 - Can Med Assoc
Background: Evidence from controlled trials encourages the intake of dietary pulses (beans,
chickpeas, lentils and peas) as a method of improving dyslipidemia, but heart health …

Regulation of brain polyunsaturated fatty acid uptake and turnover

CT Chen, JT Green, SK Orr, RP Bazinet - Prostaglandins, Leukotrienes and …, 2008 - Elsevier
The brain is particularly enriched in glycerophospholipids with either arachidonic or
docosahexaenoic acid esterified in the stereospecifically numbered-2 position. In this paper, we …

Rapid β-oxidation of eicosapentaenoic acid in mouse brain: an in situ study

…, Z Liu, M Ouellet, F Calon, RP Bazinet - … , leukotrienes and essential …, 2009 - Elsevier
Analyses of brain phospholipid fatty acid profiles reveal a selective deficiency and enrichment
in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), respectively. In order …

Unesterified docosahexaenoic acid is protective in neuroinflammation

…, DWL Ma, CN Serhan, RP Bazinet - Journal of …, 2013 - Wiley Online Library
Docosahexaenoic acid (22:6n‐3) is the major brain n‐3 polyunsaturated fatty acid and it is
possible that docosahexaenoic acid is anti‐inflammatory in the brain as it is known to be in …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

…, R Chouinard-Watkins, RP Bazinet - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …