Background— Sudden cardiac death takes the lives of more than 300 000 Americans annually.
Malignant ventricular arrhythmias occurring in individuals with structurally normal hearts …

… V, transmembrane voltage (mV); G to , maximum conductance of the channel (mS/μF); z
and y, activation gate (3 gates per channel) and inactivation gate, respectively; R(V), outward …

Sudden unexplained nocturnal death syndrome (SUNDS), a disorder found in southeast Asia,
is characterized by an abnormal electrocardiogram with ST-segment elevation in leads V1…

Objective— Hypofibrinolysis promotes atherosclerosis progression and recurrent ischemic
events in premature coronary artery disease. We investigated the role of fibrin physical …

The sudden infant death syndrome (SIDS) remains the leading cause of death in the first year
of life and has a devastating impact on the affected families. – 4 Despite the fact that there …

… Dr Dumaine was supported by postdoctoral fellowships from the Heart and Stroke
Foundation of Canada and Le Fonds de la Recherche en Santé du Québec. We thank W.-Q. …

BackgroundAdministration of the antihistamine terfenadine (Seldane) to patients may result
in acquired long QT syndrome and ventricular arrhythmias. One human cardiac target is Kv1.…

The QT interval on an electrocardiogram signifies the time required for the heart to repolarize
after depolarization. It has long been appreciated that a long QT interval predisposes …

Introduction: The principal aim of this study was to assess the efficacy of quinidine in
suppressing I Kr in vitro and in modulating the rate dependence of the QT interval in the “SQT1” …

Background— Aldosterone, the final mediator of the renin-angiotensin-aldosterone pathway,
is at its highest plasma levels at presentation for ST-elevation myocardial infarction (STEMI)…