Objective: To evaluate the efficacy and safety of perampanel 2, 4, and 8 mg/day added to 1–3
concomitant antiepileptic drugs (AEDs) in patients with uncontrolled partial-onset seizures. …

Background: Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus.
It may progress to respiratory failure, and a significant proportion of patients die. Preliminary …

Background Acute stroke patients with large artery occlusive disease (LAOD) have a distinct
pathophysiology and may respond differently to anticoagulation treatments. We compared …

Arteriosclerotic related cerebral white matter lesion (WML) is associated with increased risk
of death, stroke, dementia, depression, gait disturbance, and urinary incontinence. We …

Objectives Many antiepileptic drugs (AEDs) prevent seizures by blocking voltage-gated brain
sodium channels. However, treatment is ineffective in 30% of epilepsy patients, which might…

There is accumulating evidence to suggest that overexpression of efflux drug transporters at
the blood–brain barrier, by reducing antiepileptic drug (AED) accumulation in the seizure …

Background The optimal treatment for patients with ischaemic stroke with a high risk of cerebral
haemorrhage is unclear. We assessed the efficacy and safety of cilostazol versus aspirin…

In the majority of patients, epilepsy is a complex disorder with multiple susceptibility genes
interacting with environmental factors. However, we understand little about its genetic risks. …

Objective Understanding how symptomatic intracranial atherosclerotic disease (ICAD)
evolves with current medical therapy may inform secondary stroke prevention. Methods In a …

Aims: It remains controversial whether polymorphisms of the multidrug resistance gene
ABCB1 are associated with pharmacoresistance in epilepsy. To further study the potential …