Asthma is the most prevalent pediatric chronic disease and affects more than 300 million
people worldwide. Recent evidence in mice has identified a “critical window” early in life where …

Methods This paper arose from an extensive literature review undertaken in developing the
Canadian Healthy Infant Longitudinal Development (CHILD) study, a multicentre national …

Inert gas washout tests, performed using the single- or multiple-breath washout technique,
were first described over 60 years ago. As measures of ventilation distribution inhomogeneity, …

This document provides clinical recommendations for the management of severe asthma.
Comprehensive evidence syntheses, including meta-analyses, were performed to summarise …

Breastmilk contains a complex community of bacteria that may help seed the infant gut
microbiota. The composition and determinants of milk microbiota are poorly understood. Among …

Background Pre-school children spend an average of two-hours daily using screens. We
examined associations between screen-time on pre-school behavior using data from the …

Background Early-life exposure to household pets has the capacity to reduce risk for
overweight and allergic disease, especially following caesarean delivery. Since there is some …

Gut microbiota play a critical role in infant health. It is now accepted that breastmilk contains
live bacteria from endogenous and exogenous sources, but it remains unclear whether …

Importance Maternal overweight, which often results in cesarean delivery, is a strong risk
factor for child overweight. Little is known about the joint contribution of birth mode and …

Background Childhood asthma incidence is decreasing in some parts of Europe and North
America. Antibiotic use in infancy has been associated with increased asthma risk. In the …